Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment.Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3,