Sense and Senility: The Neuropathology of the Aged Human Brain

nly two things are certain in life, one is that all of us will inevita­ Obly grow older, the other is that at some point during or at the end of this process we shall die. Inherent to the passage of time is a deterio­ ration in the structural and functional integrity of our bodies, this pro­ gressing to such an extent that one or more organ systems will eventu­ ally begin to fail with the continued health and well-being of the individual coming under threat. Age-associated deficiencies in the mu