Osteoporosis in Older Persons

Although osteoporosis has been de? ned as “a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk,” it is not clear that osteoporosis represents a single disease as much as a similar response of bone to different pathophysiologies. In the 1940s Fuller Albright and colleagues recognized “osteoporosis of old age” and distinguished it from osteoporosis associated with t