Maturation Phenomenon in Cerebral Ischemia V

The Maturation Phenomenon, first described by Ito et al. in 1975, refers to post­ ischemic changes that develop hours or days after an ischemic insult. The delayed neuronal death of CAl pyramidal cells of the hippocampus is a classic example. The report of the phenomenon boosted research in the field, as it became evi­ dent that ischemic damage is not a sudden event but a process potentially suscep­ tible to therapeutic intervention. In September 1990, Ito and collaborators organized the First I