Immunochemistry of Proteins

The structural features responsible for the immunogenicity of certain parts of native protein molecules have been of interest to immunochem­ ists and protein chemists for over three decades. However, until re­ cently no concerted effort was (or could be) devoted to the elucidation of the complete antigenic structure of a protein. In order for these en­ deavors to be successful and meaningful, knowledge of both the amino acid sequence and the detailed three-dimensional structure of the protein is