Clinical Perspectives in the Management of Down Syndrome

The management of and attitudes toward children and adults with Down syndrome have undergone considerable changes in the course of the condi­ tion's long history (Zellweger, 1977, 1981, Zellweger & Patil, 1987). J. E. D. Esquirol (1838) and E. Seguin (1846) were probably the first physicians to witness the condition without using currently accepted diagnostic designa­ tions. Seguin coined the terms furfuraceus or lowland cretinism in contradis­ tinction to the goiterous cretinism endemic