Chemical-specific Adjustment Factors for Interspecies Differences and Human Variability

The objective of this document is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose/concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Programme on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Expos